A team of more than 80 researchers working across four continents have identified a set of proteins in the blood that accurately predict lung cancers more than five years before diagnosis. The scientists also found early evidence that an existing anti-inflammatory drug could significantly reduce lung cancer risk in people with elevated concentrations of these proteins, which they linked to inflammation. More research is needed before a test based on these proteins could be ready for use in patients. And scientists would still need to run a randomized trial to determine whether the drug prevents lung cancers. Still, outside experts said the findings, which were published on Thursday in the journal Cell, offer a promising starting point toward a long-held public health goal…

Led by Dr. Swanton, Dr. Tej Pandya, a Ph.D. student, and other researchers took a set of 48,000 blood samples from the UK Biobank and used machine learning to identify 14 proteins associated with the development of lung cancer. When the researchers looked at the presence of those proteins and also took into account a patient’s age, smoking status and history of lung disease, they were able to predict who would develop lung cancer more accurately than the best risk assessment models currently in use…

Using mouse and cell models, the scientists showed that these proteins increased when a specific inflammatory pathway was activated. Smoking and air pollution can activate that pathway. This adds to the evidence that it isn’t just genetic mutations caused by smoking, pollution or other factors that are driving lung cancers. Rather, Dr. Swanton said, the findings suggest that “smoke causes mutations and inflammation, which together cause cancer.” They also found that the signature was increased in people who later developed chronic obstructive pulmonary disease and pulmonary fibrosis, pointing to a common inflammatory environment upstream of all three diseases.

Even for Jamie Dimon, the banking titan who’s not known to mince words, it was a surprising shot across the bow when he described a fellow financier as “full of sh*t.” “No one’s gonna bow down to this guy or that company,” Dimon told Fox Business last week. “This guy” being Brian Armstrong, and “that company” being cryptocurrency exchange Coinbase. The Dimon-Armstrong tension isn’t new, but it is boiling over publicly as the Senate inches closer to a floor vote on the crypto industry’s No. 1 legislative priority, known as the Clarity Act. Dimon, a longtime crypto skeptic, broadly supports crypto regulation but takes issue with a provision in the Clarity Act that would allow companies like Coinbase to “effectively pay interest on deposits… without the protection they should have.”

The spicy comment about Armstrong came after Dimon rattled off other concerns about the Clarity Act, including what he sees as its insufficient anti-money-laundering and know-your-customer safeguards that banks have had in place for decades… “If (Armstrong) takes deposits like a bank, he should have bank rules,” Dimon said in the Fox Business interview… The immediate concern from banks (and many consumer advocates) is that crypto exchanges like Coinbase would, in the grand tradition of Silicon Valley innovation, lure customers in with huge rewards and then phase those benefits out over time. Deposits in a crypto exchange are also not insured by the federal government the way bank deposits are, but that’s the kind of fine print that customers tend to overlook until it’s too late. JPMorgan Chase spokesperson Trish Wexler underscored that the bank wants the bill to pass, with some “fixes,” like prohibiting rewards on stablecoin holdings and strengthening anti-money-laundering guardrails.

Armstrong pointed to restrictions on rewards paid to idle cryptocurrency balances and disclosures on stablecoins as part of a handful of policies included in the bill to appease the banking industry’s requests. “I think it’d be good for the banks,” Armstrong said of the bill. “It would be great for crypto companies as well … Hopefully we can get past the absolutisms and just see if we can get this bill over the finish line.”

“It’s not just a crypto story, it’s a broad deregulation of our securities markets story,” Hilary Allen, a law professor at American University who specializes in banking and cryptocurrency, said in an interview. And that should concern everyone, Allen says, even if they have no investments at all, because “if we get a financial crisis in this space… no one comes out of that unscathed.”

Beyond labor concerns, art theft worries, and environmental issues, the most straightforward reason AI art has been unpopular is that many players find it hideous. We’ll find out for sure whether Tomb Raider: Legacy of Atlantis’ use of AI is particularly blatant when it comes out in February 2027.

The lawsuit was filed Wednesday in Utah’s 3rd District Court by the Alliance for a Better Utah and the group of anonymous residents. The plaintiffs hope to challenge the constitutionality of the Military Installation Development Authority (MIDA) — a special entity that oversees the data center’s proposal — and its approval of the project, a spokesperson for the nonprofit said. Attorney David Irvine, who is representing the plaintiffs, alleges that MIDA is exercising powers as an unelected body that “the Utah Constitution never authorized.” “Under the Stratos plan, it would hold permanent, irrevocable control over public health, safety, taxation, and land use across tens of thousands of acres of Box Elder County, with no voter recourse,” he said in a statement.

The lawsuit alleges that allowing MIDA to oversee the data center’s development “irrevocably” cuts off Box Elder County citizens’ rights by not allowing sufficient public input in the project. “The Stratos Project Area Plan, and actions taken by MIDA and the Commission to enact the same, puts lawmaking power respecting questions of public health, safety, welfare, morals, taxation, zoning, land use, and the like, in relation to a significant swath of county territory in a non-elected MIDA Board,” the complaint reads.

In addition to MIDA and the Box Elder County Commission, the lawsuit names Utah Senate President J. Stuart Adams and state Sen. Jerry Stevenson, who also serve as MIDA board members. Irvine said Adams and Stevenson’s presence on the MIDA board as active legislators “appears to violate the prohibition on holding more than one office of public trust simultaneously,” and claimed this should render the data center’s approval “null and void.”

Scientists have been aware for some time that feeding black holes launch powerful outflows of material around them, including jets and winds. Winds are caused when matter falling to the black hole is accelerated to near light-speed, generating pressure that pushes infalling material away. That has been seen with ravenously feeding black holes before, but not the barely feeding Sgr A*. Its sparse consumption of material and the fact it is obscured by the plane of the Milky Way from our vantage point have made tracing this wind difficult.

Gorski’s Northwestern colleague and team co-leader Lena Murchikova pointed out that the scientists were the first to detect molecular gas very close to Sgr A* feeding the supermassive black hole. That makes Sgr A* reassuringly like other supermassive black holes. “The wind is not powerful, and its direction probably wanders with time. It shows that our black hole is not unique, and our place in the universe is not unique,” Murchikova added. “To observe our own black hole, we have to look through the plane of our galaxy. That means we have to peer through gas, dust and ionized structures, and you can’t really see through all of that easily.”

While the team’s results confirm that Sgr A* is extremely quiet compared to the supermassive black holes that sit in bright, turbulent regions of other galaxies called active galactic nuclei (AGN), this black hole wind is no slouch. In fact, the scientists think that it has been raging for around 20,000 years. “The majority of other galaxies spend most of their lives in a state where they are not particularly active,” Murchikova said. “But we can only see them when they are in a fireworks stage. It is very attractive to study black holes when they are in the fireworks stage, but that’s not actually their dominant state. “Sgr A* finally gives us a window into the life of a black hole in this quiet state.”

Just over a year ago, the Trump Administration issued an executive order meant to accelerate the development of nuclear power in the US. While an entire startup ecosystem has developed around the use of different — and typically smaller — reactor designs, only one of them has been fully licensed so far, and there are no plans to actually build any instances of that design.

The executive order directed the Department of Energy to have three different reactor designs reach criticality in a bit over a year. On Thursday, a startup called Antares announced that a test reactor it had placed at the Idaho National Laboratory had reached criticality, making it the first new design to cross this threshold. Criticality means that the nuclear reactions inside the hardware had become self sustaining; it does not mean the reactor had started to generate power. […]

At the moment, Antares is just testing what it calls a Mark 0 reactor, which is not connected to the power-generation portion. Instead, it’s being used to validate the company’s modeling of the physical conditions in its reactors and generate safety data that can be used during licensing applications. Attempts to run the entire system, including electrical generation, are expected to happen next year. While the work was done at a Department of Energy Lab, the company is working with the Department of Defense’s Project Pele program for developing a mobile nuclear reactor. The company has also received support from NASA.

[…] From the beginning, he suspected that the subframe field contained encrypted transmissions because the data was so random. “Random data is actually very unusual to get in nature,” Murdoch said. “If you see it, either it’s been carefully designed to be random — but then, why is someone sending out random data? — or it’s encrypted data. I thought encrypted data is by far the most likely explanation.” He returned to the subframe on and off over the years, and solicited guesses about its content on Stack Exchange in 2023. Ahmed Kamruddin, a master’s student at UCL, developed the project further in 2025. Then, this year, Murdoch put the last pieces of the puzzle together over several weeks by analyzing open archive Global Navigation Satellite System (GNSS) recordings collected since 2007 and kept by GFZ Helmholtz Centre for Geosciences.

This dataset included more than 12 million observations of Subframe 4, Page 17, yielding 3,994 unique 176-bit messages. Within this corpus, Murdoch pinpointed key-repeating “sentinels” including a pattern that appeared in February 2010 and was broadcast on and off across dozens of satellites for more than a decade. Murdoch discovered that this particular sentinel was transmitted by all 31 operational satellites within a window of a few hours on May 26, 2011, potentially heralding the activation of a new operational system. He confirmed that this timeline coincided with the rollout of the military’s Over-the-Air Distribution (OTAD) and the Over-the-Air Rekeying (OTAR) by cross-referencing declassified documents, including a 2015 presentation about the dates of the operation.

“There was a perfect match between the timeline and that presentation and the change points that were automatically identified from the data,” Murdoch said. “That was the smoking gun that made me think: This is what it’s for.” These automated systems replaced the cumbersome manual distribution of cryptographic keying material, allowing military GPS receivers around the world to be rekeyed remotely through satellite broadcasts rather than through onsite procedures. For the next 11 years, this expansive rekeying operation was overlooked in public GPS data. In 2022, the system entered a new phase, according to Murdoch’s analysis. The shift was characterized by a slowing in the message rotation rate. Later, in December 2023, broadcasts carrying a distinctive “TEXT” prefix emerged then gradually spread across the constellation.

Murdoch isn’t sure what explains the recent transition, though it could be a possible modernization of the infrastructure or the introduction of a new protocol. But to him, the bigger takeaway is that the signals were always available for anyone willing to take a closer look, a discovery that suggests that there could be more revelations hidden for the cryptographically curious among us. “Every receiver in the world decodes Subframe 4, Page 17,” Murdoch said in his new article. “Almost none of them have ever looked at it. The lesson generalizes: There is more to learn from the bytes already arriving at our antennas than from the bytes we wish were specified differently. The data are publicly available. The signal is overhead, twice a day, every day.”

The deal is similar in length and scope to the one SpaceX announced with Anthropic in late May. As part of that deal, Anthropic agreed to pay SpaceX $1.25 billion per month through 2029 to rent all the available compute from its Colossus 1 data center near Memphis, Tennessee that xAI — now part of SpaceX — originally built for its own artificial intelligence efforts.

Google’s deal appears to be paying for roughly half the amount of compute that Anthropic has access to at Colossus 1. SpaceX didn’t say which specific data center Google would be using. CEO Elon Musk has previously suggested his company would reserve the Colossus 2 data center for xAI. Anthropic was significantly limited in its compute capacity prior to its deal with SpaceX, raising usage limits on the same day the deal was announced. Google is in a very different position, with some estimates naming it as the world’s largest single owner of AI compute.

[…] Also like the Anthropic deal, the agreement with Google includes a cancellation clause. Both SpaceX and Google have the option to terminate the agreement with 90 days notice after December 31, 2026. Google’s access to the data center will ramp up “through September at a reduced fee,” according to the filing. “If we fail to deliver access to the committed amount of GPUs by September 30, 2026, then following a one-month grace period, Google may immediately terminate the agreement or accept the number of GPUs provided” with a reduction in the monthly fees, it reads.

Now, with stocks in plunge mode — the Nasdaq down nearly 4% on Friday — bitcoin finds itself perfectly correlated. “Short term, Bitcoin feels like swallowing broken glass,” wrote Jeff Swanson Friday. “The chart goes up. It goes down. It makes grown men cry into their Robinhood accounts and CNBC anchors smugly declare the funeral, for the eleventh time.” “Here’s what uncomfortable people don’t understand: the discomfort is the yield. Every paper-handed panic seller is handing their future to someone with a longer time horizon and a colder storage device.”

[…] Earlier, Shielded Labs, a nonprofit developer on the privacy token system, disclosed a critical vulnerability in Zcash’s (ZEC) Orchard privacy pool that could have threatened the integrity of the token’s supply. The vulnerability, if exploited, could have allowed an attacker to create an unlimited number of counterfeit ZEC tokens, completely undetected. “Think of it as someone secretly gaining access to the Federal Reserve’s dollar printing press, except in this case, even the Fed wouldn’t be able to tell these extra dollars were printed,” wrote Omkar Godbole. Importantly, the vulnerability was discovered with help from Anthropic’s recently released Opus 4.8 AI model, raising difficult questions for the entire crypto industry. More to come on that. ZEC is now down 42% over the past 24 hours.

Earlier this year Nieman Lab broke the story that major news publishers, including The New York Times, The Guardian, and USA Today Co., had started blocking the Internet Archive for fear that AI companies might scrape the nonprofit’s repositories for training data. As one of the last bastions of archival history, that is, in case you’re not aware, not very good for the public interest. Four months later and Nieman Lab now notes that the number of news outlets blocking the archive has soared to around 340 organizations:

“Our new analysis shows that more than 340 local news sites across the United States are now limiting the Internet Archive’s ability to access and preserve their stories. Many sites in our sample are owned by five of the seven largest local news publishers in the country: USA Today Co., McClatchy, Advance Local, MediaNews Group, and Tribune Publishing. The latter two are both subsidiaries of the “vulture hedge fund” Alden Global Capital.”

[…] Regardless of motivation, hiding whatever local news remains behind paywalls, then blocking it from the Internet Archive, in turn makes it harder for everyone else to do real journalism that relies on the historical record, local journalists tell Nieman Lab: “I cover news within a larger news desert in New York’s Rockland, Sullivan, and Rockland counties. This means I need to heavily rely on archival data of old news articles from now deceased, or zombie-fied, media outlets,” wrote B.J. Mendelson, the editor of The Monroe Gazette newsletter, in one recent petition signed by over 200 journalists. “Without the Internet Archive, my [work] would be incredibly difficult to do.”

According to the tender notice published in February 2025, the contract covers around 17 percent of payments made through GOV.UK Pay but more than 70 percent of its organizations and includes the only option allowing users to start taking payments within one working day. At that point the contract had an estimated maximum value of £49 million, although with no guarantees over volume.

In a blogpost about the contract award on 2 June, GDS said it will migrate around 1,000 services to the new supplier. “We will make migration as straightforward as possible while complying with Know Your Customer legislation that protects everyone from fraud,” wrote Alan Maddrell, senior content designer for the service. “Most importantly, there will be no discernible difference for paying users and no loss in functionality.”

He added that the change of supplier will help introduce new options including pay by bank, which transfers money directly between bank accounts using open banking services and avoids the need to type in card details. GDS will continue to use WorldPay to process payments for central government, linked organizations and NHS bodies.

The American Business Software Alliance (BSA) does not consider mandatory open-source licensing to be an appropriate indicator of sovereignty. This is among the “pointed messages” they sent to the French government consultation (closed) today. “What protects Europe is the ability to govern, audit, and mitigate risk, not where a company files its corporate papers,” said Thomas Boue of BSA. “Criteria of this kind raise costs, reduce access to best-in-class security solutions, and risk conflicting with the EU’s international trade commitments.”

There’s been a lot of pushback in recent months around the impact of AI data centers on local communities, with the use of water being a key issue for many. Google, in an expansion of its “water stewardship” programs, is making commitments that include replenishing more water than it uses at its data center sites. AI data centers go through a lot of water use in cooling the hardware used to power models, and Google is no exception. While Google stands by saying that the impact of AI data centers on U.S. water consumption is “small,” it also says it is focusing on “protecting local water resources in all aspects of our data center operations.”

In a post, Google explains five new commitments regarding water use at its data centers in the U.S. These include replenishing more water than is consumed at data centers, helping local utilities to modernize water infrastructure, using air-cooled solutions in areas where watersheds are at risk, “transparently” reporting water use at data centers, and focusing on “alternative and reclaimed” water solutions. […] In a linked paper (PDF), Google says it will replenish 120% of the water it uses at data center sites by 2030. Google is also committing $17 million to new water stewardship projects in Georgia, Iowa, Michigan, Minnesota, Missouri, Nebraska, and Texas in addition to 165 other projects already in place throughout the U.S.

The news should ease the worries of many an expecting gamer, given today’s constant worries about AI servers slurping every RAM and NAND chip on the face of the earth, as well as Valve’s own statements about component scarcity delaying the release. Plus, the company always works on its own schedule, so much so that Valve Time is a term.

The release of the Machine has been taking flak, given that while Valve was initially hoping for an estimated $600 to $800 price — in the ballpark of the higher-end consoles — the rumored pricing is climbing around or over $1000. This fact is somewhat corroborated by a February statement from a Valve executive who, like most anyone in the world, stated the price revision was due to the AI-driven component shortage.

The four astronauts of NASA’s Crew-12 mission on the station — two US astronauts, a French astronaut and a Russian cosmonaut — received orders from NASA mission control at 9.04am ET (2pm BST) on Friday to enter their Crew Dragon spacecraft docked to the station and don their spacesuits in case the air leak warranted an emergency evacuation, a NASA official said.

NASA and Russia’s space agency Roscosmos, the station’s two primary operators, have debated for months over the cause and potential fixes of small air leaks onboard Russia’s Zvezda service module, a key structure of the football-pitch-sized laboratory. The air leaks have been relatively minor in recent months. But on Monday the problem escalated from a pound of air per day to two pounds (0.9kg) a senior Nasa official told Reuters on condition of anonymity.